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M94A0702.TXT
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1994-10-21
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Document 0702
DOCN M94A0702
TI Progressive multifocal leucoencephalopathy--the Fairfield Hospital
experience.
DT 9412
AU Marshall C; Jennens I; Fairfield Hospital, Vic.
SO Annu Conf Australas Soc HIV Med. 1993 Oct 28-30;5:30 (abstract no. TC8).
Unique Identifier : AIDSLINE ASHM5/94348953
AB Progressive multifocal leucoencephalopathy (PML) is a cerebral infection
caused by JC virus occurring in immunocompromised people. It has been
well described in transplant recipients requiring immunosuppressive
therapy and more recently in people immunosuppressed with human
immunodeficiency virus (HIV). PML is estimated to occur in 1% of persons
with AIDS. Fairfield Infectious Diseases Hospital has treated 716 people
with Category IV disease or AIDS. PML has been diagnosed in 12 of these
patients. We conducted a search of hospital records to determine the
clinical features of patients with HIV infection and PML. As opposed to
transplant recipients where PML is multifocal, PML complicating HIV
infection presented with distinct neurological deficits with unifocal
lesions on brain imaging on 8 occasions. All patients were homosexual
males. Median CD4 count at presentation was 45 (range 10-330), and in
9/12 patients PML was their AIDS defining illness. Median survival
following a diagnosis/presentation was 2 months (range 0.5-6 months).
Three patients received treatment with IV Ara C, but treatment did not
appear to improve neurological deficits or prolong survival.
DE AIDS Dementia Complex/*DIAGNOSIS/IMMUNOLOGY/MORTALITY Follow-Up Studies
Human Leukocyte Count Leukoencephalopathy, Progressive
Multifocal/*DIAGNOSIS/IMMUNOLOGY/ MORTALITY Neurologic Examination
Polyomavirus hominis 2 Survival Rate T4 Lymphocytes/IMMUNOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).